Search results for " Chemotherapy-induced nausea and vomiting"

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NEPA as antiemetic prophylaxis after failure of 5HT3-RA plus dexamethasone in patients receiving carboplatin and gemcitabine chemotherapy: A monocent…

2020

Introduction Chemotherapy-induced nausea and vomiting (CINV) may affect adherence to planned chemotherapy treatments and compromise patients’ quality of life during the therapy. NEPA is an oral fixed combination of netupitant, a highly-selective NK1-RA and palonosetron, a 5HT3-RA, approved for the prevention of acute and delayed CINV. The aim of this study was to evaluate the efficacy and safety of NEPA with dexamethasone for CINV prophylaxis in the challenging setting of carboplatin and gemcitabine combination chemotherapy, after failure of prophylaxis with 5HT3 receptor antagonist. Methods Eligible patients were undergoing carboplatin and gemcitabine combination chemotherapy for metastati…

0301 basic medicineOncologymedicine.medical_specialtyNauseamedicine.drug_classmedicine.medical_treatmentOndansetron03 medical and health scienceschemistry.chemical_compound0302 clinical medicineInternal medicinemedicineAntiemeticPharmacology (medical)carboplatin Chemotherapy-induced nausea and vomiting gemcitabine netupitant NSCLC ondansetron ovarian cancer palonosetron urothelial cancer dexamethasoneChemotherapybusiness.industryGemcitabineCarboplatin030104 developmental biologyOncologychemistry030220 oncology & carcinogenesisVomitingmedicine.symptombusinessmedicine.drugChemotherapy-induced nausea and vomiting

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